International Journal of Drug Delivery and Nanotechnology
 
Year Of Started:      2015 Published By:   SBT JOURNALS
Frequency:   Quarterly ISSN:                2455-2747

FORMULATION AND EVALUATION OF FAST DISSOLVING TABLET OF IBUPROFEN BY SUBLIMATION METHOD

B.Rama*, Grace Rathnam, Ubaidulla, Swetha, Priyan

The aim of the proposed work was to formulate and characterize fast dissolving tablets of Ibuprofen for rapid dissolution, which may produce rapid onset of action. In this work, fast dissolving tablets of Ibuprofen were prepared by sublimation method with a view to enhance patient compliance. Sodium starch glycolate in different concentration was used as super-disintegrant, and Ammonium carbonate (20 -30 % w/w) was used as subliming agent. The prepared batches of tablets were evaluated for Physico-chemical properties, wetting time, in-vitro disintegration and in-vitro drug release. Among the prepared formulations, the formulation (F4) contain-ing 4% w/w of sodium starch glycolate and 25% w/w of ammonium carbonate as a subliming agent was found to be promising with disintegration time of 28 seconds, wetting time of 18 seconds and percentage of drug release of 99.5% for 30 mins. So we can conclude F4 is the best formulation when compared to all other formulations.

 
Full Text Attachment
Views : 786 Downloads : 12

 

Tell a Friend